Composition
active ingredient:
1 bottle contains 10.0 g of silicon dioxide (highly dispersed); 1 sachet contains 2.0 g of silicon dioxide (highly dispersed).
Dosage form
Powder.
Main physicochemical properties: light amorphous white powder, tasteless and odorless.
Pharmacotherapeutic group
Enterosorbents. ATX code A07V S.
Pharmacological properties
Pharmacodynamics.
Atoxil is an enterosorbent with pronounced sorption properties, exhibits detoxification, antimicrobial and wound healing effects. Adsorbs from the digestive tract and removes endogenous and exogenous toxic substances of various origins from the body, including food and bacterial allergens, microbial endotoxins and other toxic substances, toxic products formed during the decay of proteins in the intestine.
Promotes the transportation from the internal environment of the body (blood, lymph, interstitium) to the digestive tract due to concentration and osmotic gradients of various toxic products, including medium molecules, oligopeptides, amines and other substances, with subsequent excretion from the body.
Pharmacokinetics.
The drug is practically not absorbed from the intestines.
Indication
Acute intestinal diseases accompanied by diarrheal syndrome (salmonellosis, food poisoning); in the complex therapy of viral hepatitis A and B.
Externally - treatment of purulent wounds, trophic ulcers and burns.
Contraindication
- Hypersensitivity to silicon dioxide;
- Gastric and duodenal ulcer in the acute stage;
- Ulcers and erosions of the intestine;
- Intestinal obstruction.
Interaction with other medicinal products and other types of interactions
With the simultaneous use of the drug Atoxil with acetylsalicylic acid, platelet disaggregation processes were enhanced.
In complex therapy with nicotinic acid and simvastatin, Atoxil exhibits a synergistic effect - it helps reduce the level of atherogenic fractions of the blood lipid spectrum and increase the level of high-density lipoprotein cholesterol.
The use of Atoxil during intracorporeal sorption detoxification in combination with standard antiseptic solutions (furatsilin, bifuran, trifuran, chlorhexidine bigluconate) increases the effectiveness of the treatment of purulent-inflammatory diseases.
Application features
It is forbidden to use dry powder orally.
Atoxil, when used in complex therapy, should be taken 1 hour before taking other oral medications due to their possible absorption and, accordingly, a decrease in effectiveness.
Use during pregnancy or breastfeeding.
Due to the lack of data on the use of Atoxil during pregnancy or breastfeeding, the use of the drug is not recommended.
The ability to influence the reaction speed when driving vehicles or other mechanisms.
No effect.
Method of administration and doses
Atoxil is taken as a suspension for internal use. The contents of 1-2 sachets (2-4 g) should be thoroughly mixed in 50-100 ml (¼-½ cup) of neutral still or cooled boiled water until a homogeneous suspension is formed.
Open the bottle with the powder, add neutral still or cooled boiled water to the 250 ml mark, mix until a homogeneous suspension is formed.
The daily dose for adults and children over 7 years of age is 12 g, if necessary, the daily dose can be increased to 24 g;
For children from 1 to 7 years old, the daily dose is 150-200 mg per 1 kg of body weight. The daily dose should be divided into 3-4 doses.
The maximum single dose should not exceed half the daily dose.
The prepared aqueous suspension of the drug should be taken orally 1 hour before meals or taking medications.
In acute intestinal diseases, it is advisable to start treatment with a maximum single dose of 7 g for adults and children over 7 years of age, taking the drug 2-3 times a day. If the patient cannot take the enterosorbent on his own, the suspension of the drug Atoxil should be administered into the stomach through a tube.
In acute intestinal diseases, the course of treatment is 3-5 days. In severe cases, the treatment period can be extended to 10-15 days.
The course of treatment for viral hepatitis depends on the severity of the disease and is 7–10 days.
External use. After cleaning the wound, apply the powder in a layer of 3-5 mm and cover with a dry aseptic bandage. Dressings should be done a day before cleaning the wound.
Children: Do not administer the drug to children under 1 year of age.
Overdose
There were no reports of overdose.
Side effects
The drug is usually well tolerated. In rare cases, constipation may occur.
Expiration date
3 years.
Storage conditions
Store in the original packaging out of the reach of children, at a temperature not exceeding 25 °C.
Store the prepared suspension in a tightly closed bottle at a temperature of 2°C to 8°C for no more than 32 hours.
Packaging
10 g of powder in a bottle, 1 bottle in a cardboard pack.
2.0 g of powder in a sachet, 20 sachets in a cardboard box.
Vacation category
Without a prescription.
Producer
LLC "Orisil-Pharm".
Address
Ukraine, 77300, Ivano-Frankivsk region, Kalush, Zavodska st., 1B.
