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It is impossible to imagine modern medicine without antibiotics. Along with many indisputable advantages, their use is often accompanied by side effects.

One of the most frequent symptoms is antibiotic-associated diarrhea.

We can talk about AAD if, on the background of taking antibacterial drugs, there are at least three episodes of unformed stool for two or more days. Symptoms of AAD in most patients appear during antibiotic treatment, and in 30% patients - after 1-10 days after its termination.

The frequency of occurrence of AAD depends on the type of prescribed antibiotic and is 2-30%. Despite the fact that almost all antibiotics can cause diarrhea, there are also the most "evil culprits": clindamycin, amoxicillin potentiated with clavulanic acid, ampicillin, erythromycin, clarithromycin (Maev I.V., Samsonov A.A., Golubev N.N., 2007).

It is fundamentally important to distinguish two forms of AAD, which differ significantly not only in the mechanism of development, but also in clinical manifestations, as well as prognosis: idiopathic AAD and diarrhea caused by a microorganismClostridium difficile (pseudomembranous colitis, which makes up 10-20% of all AADs) (Kostyukevich O.I., 2009).

The main and often the only symptom of idiopathic AAD is a watery stool, usually without an increase in body temperature and leukocytosis. Sometimes a violation of the stool is accompanied by a painful abdominal syndrome associated with increased intestinal motility.

One of the main causes of idiopathic AAD is dysbiosis — a change in the quantitative and qualitative composition, as well as the properties of the intestinal microflora. The fact is that when prescribing antibiotics, their influence on the microbiocenosis of the intestine is rarely taken into account, which leads to the suppression of the growth of not only pathogenic microorganisms, but also normal microflora (Duka E.D., Kramarev S.A., 2007).

Dysbiosis leads to a decrease in colonization resistance and active reproduction of microorganisms insensitive to the antibiotic used. The risk of developing dysbacteriosis increases with long-term antibacterial therapy (more than 10 days), frequent use of antibiotics, as well as with the use of low-quality drugs or the wrong mode of their administration.

DIFFICULTIES OF THERAPY

In most cases, the diarrhea stops on its own after the withdrawal of the "culpable" drug. However, sometimes additional treatment is required. If the main mechanism of diarrhea is a change in microflora, doctors prescribe pre- and probiotics. At the same time, correction of dysbiosis in AAD often does not have the desired effect, which is due to the low survival rate of bacteria in the composition of probiotics. The fact is that lactobacillus and bifidobacteria introduced with the help of probiotics die under the influence of toxins produced by conditionally pathogenic flora. Clinical and experimental studies have shown that under the action of gastric juice and bile, probiotics lose up to 90% their activity before they enter the intestines. In addition, it takes 7-8 hours for bifidobacteria to get out of anabiosis, and 5 hours for lactobacilli, so it is obvious that in conditions of diarrhea, they simply do not have time to stay in the intestines. And finally, fungi of the genus are a frequent cause of dysbiosis and AADCandida, and probiotics practically do not have an antagonistic effect on these microorganisms.

As a result, long-term treatment, the need to use different additional drugs, the chronicity of the process, and the increase in the cost of therapy.

FOR TREATMENT AND PREVENTION

An effective alternative to probiotics for AAD is the use of combined preparations containing silicon sorbents in combination with the natural prebiotic lactulose. Highly active silicon sorbents have successfully proven themselves in the elimination of gastrointestinal disorders (diarrhea, bloating, heaviness, nausea), they have a pronounced sorption effect, effectively inhibit the growth and development of pathogenic and conditionally pathogenic microflora, in particular, they show high sensitivity to fungi of the genus Candida. In turn, the natural prebiotic lactulose promotes colonization of the intestine with bifidobacteria and lactobacilli, activates the processes of growth and restoration of the intestinal protective microflora.

Such preparations in the form of a gel can be prescribed both for the treatment of AAD and dysbiosis, and for their prevention from the first days of antibiotic therapy. In addition, in order to prevent AAD, antibiotics should be used only according to indications, antibacterial therapy should be stopped in a timely manner after achieving a clinical effect, and the drug should be immediately canceled if diarrhea and other symptoms appear.

In their practice, doctors often do not pay due attention to the undesirable effects of antibacterial drugs. Meanwhile, antibiotic therapy often leads to the development of dysbiosis, one of the most frequent clinical manifestations of which is antibiotic-associated diarrhea (AAD).

DOUBLE PROTECTION

Eliminal gel is an innovative drug created for the effective and rapid restoration of intestinal microflora for the purpose of prevention and treatment of dysbiosis and AAD. The drug contains a highly active silicon sorbent in combination with the natural prebiotic lactulose. Thanks to the double formula, Eliminal gel has a targeted effect on the removal of harmful bacteria and enterotoxins, and also restores intestinal microbiocenosis, stimulating the growth and development of normal flora.

On the one hand, silicon sorbent adsorbs and removes from the body bacterial enterotoxins, allergens, toxic products that are formed in the process of rotting and fermentation in the intestine. In addition, it has a mediated bacteriostatic and bactericidal effect against kpathogenic and conditionally pathogenic bacteria, as well as fungi of the genus Candida.

On the other hand, the natural prebiotic lactulose promotes rapid colonization of the intestine with bifido-lactobacteria, increasing their quantity by 30-50%, activates the processes of growth and restoration of its own protective microflora. Lactulose changes the pH factor of the intestines to the acidic side, which contributes to the suppression of the growth of pathogenic and conditionally pathogenic bacteria, as well as the optimal action of digestive enzymes. Due to the formation of short-chain fatty acids, lactulose provides protection and regeneration of the intestinal mucosa, restores the permeability of the intestinal wall damaged by enterotoxins.

Eliminal gel is taken 2-3 stick packs per day for 7-10 days.

It is not recommended for patients with phenylketonuria, gastric ulcer and duodenal ulcer exacerbation, gastric or intestinal bleeding, intestinal obstruction.

WHY ELIMINAL GEL?

Among the advantages of Eliminal gel, we can highlight: fast and effective colonization of beneficial bacteria, stimulation of their growth and development; effective normalization of parietal intestinal digestion, elimination of diarrhea, flatulence; economic benefits due to the rapid elimination of symptoms of dysbiosis and intestinal disorders; convenient shape in stick-packages for a single intake and a pleasant barberry taste.